Introduction
There are stringent regulations for the manipulation and production of genetically modified organisms.
One of the requirements is that this work must be carried out in a CL3 facility.
A top academic University was encountering leakage issues during its fumigation cycles with high levels of fumigant detected within plant spaces.
A full evaluation of the facility and services was required.
Scope of Works
- Full peer review of the design of the CL3 facility
- Identifying solutions to the issues being encountered
- Identification of areas of regulatory non-compliance and mechanical performance
- Re-positioning of the mechanical safety components to minimise the fumigation envelope.
- Modifications made to improve the ductwork and sealability of the air delivery system.
- New tight shut dampers were procured and fitted.
- Safe change housings were removed and ceiling mounted terminal HEPA housings installed within the labs.
- Control system modifications were made to integrate the new plant into the fumigation strategy for the facility.
- At the completion of the works the CL3 suite underwent quantitative and qualitative leakage testing
- Provide a benchmark metric for the facility for future regular testing.
